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科學及驗證

經過十多年研究發展,安智生醫將7,000多個基因簡化,精算為瑞可盈®乳癌復發風險檢測(Amwise RecurIndex),此技術透過亞洲特有的乳癌基因表現圖譜分析,已成功驗證超過1,200位台灣與新加坡病例,效果顯著,且研究成果及技術已發表於數個國際知名醫學及科學期刊。

  • 診斷技術
  • 文獻發表

乳癌是一種異質性極高的疾病,即便臨床期別相同,未來復發機會也可能有很大的差異。乳癌的復發可分為局部復發(local regional recurrence, LRR)與遠端轉移(distant metastasis)。透過術後放射線治療可減少局部復發,術後接受化學藥物治療則可減少遠端轉移。

瑞可盈®乳癌復發風險检测技術的核心價值,在於能精準解碼病人基因,判斷局部復發與遠處轉移的風險,給予病人最佳化的個人化醫療。

若病人為低風險族群,則可避免過度化學藥物治療與放射線治療;若病人為高風險族群,則可供醫師增加化學藥物治療及放射線治療之輔助參考。

透過這樣的進階分析,能讓病人在早期發現罹癌時接受必要治療,減少家庭及社會的長期負擔,達到個人化精準醫療、降低死亡率。

  1. An Eighteen-Gene Classifier Predicts Locoregional Recurrence in Post-Mastectomy Breast Cancer Patients.
    Skye H. Cheng, Chen-Fang Horng, Tzu-Ting Huang, Erich S. Huang, Mei-Hua Tsou, Li-Sun Shi, Ben-Long Yu, Chii-Ming Chen, and Andrew T. Huang.
    EBioMedicine. 2016 Mar; 5: 74–81
  2. Validation of Gene Expression Profiling in Prediction of Locoregional Recurrence for Breast Cancer Patients after Surgery.
    Skye H Cheng, Cheng-Fang Horng, Tzu-Ting Huang, Mei-Hua Tsou, Li-Sun, Shih, Ben-Long Yu, Stella Y. Tsai, and Chii-Ming Chen.
    San Antonio Breast Cancer Symposium. Dec 8-12, 2015, San Antonio Texas USA
  3. Gene Expression Profiling in Prediction of Distant Recurrence in HR (+) and HER2 (-) Breast Cancer Patients.
    Skye H Cheng, Tzu-Ting Huang, Cheng-Fang Horng, Nicolas Pennarun.
    Human Genomics, Nov 8-10, 2015, Singapore.
  4. Validating a Prognostic Scoring System for Post Mastectomy Locoregional Recurrence in Breast Cancer.
    Cheng SH, Tsai SY, Yu BL, Horng CF, Chen CM, Jian JJ, Chu NM,Tsou MH, Liu MC, and Huang AT, Prosnitz RL.
    Int. J. Radiation Oncology Biol. Phys. 2013 Mar 15; 85(4):953-8
  5. Genomic Prediction of Loco-regional Recurrence Following Mastectomy in Breast Cancer.
    Cheng SH; Horng CF; West M; Huang, E; Pittman J; Tsou MH; Dressman H; Chen CM; Nevins JR; Huang AT.
    J Clinical Oncology 2006; Volume 24: 4594-4602
  6. Prognostic Index Score and Clinical Prediction Model of Local Regional Recurrence Following Mastectomy in Breast Cancer Patients.
    Cheng SH; Horng CF; Pittman J; Tsou MH; Chen CM; Tsai SY;West M; Huang AT
    Int. J. Radiation Oncology Biol. Phys. 2006; 64(5): 1401-1409
  7. Gene expression predictors of breast cancer outcomes.
    Huang E, Cheng SH, Dressman H, Pittman J, Tsou MH, Horng CF, Bild A, Iversen ES, Liao M, Chen CM, West M, Nevins JR,and Huang AT.
    Lancet 2003; 361: 1590-96.